Journal:
Article Title: Characterization of Novel Antimicrobial Peptoids
doi:
Figure Lengend Snippet: Activities of DHAA and related peptoid compounds against gram-positive and gram-negative bacteria a
Article Snippet: Likewise, dimer peptoids are defined as a peptoid backbone with two substituted nitrogens. table ft1 table-wrap mode="anchored" t5 TABLE 1 caption a7 Strain (phenotype) b MIC (μM) of: MIC (μg/ml) of: DHAA 26240 29498 29496 32133 33090 33091 33092 33670 33671 Gentamicin Vancomycin S. aureus ATCC 29213 20 10 20 20 10 10 10 10 5 10 ≤1 ≤1 S. aureus ATCC 25923 20 10 20 20 10 20 10 10 5 20 4 ≤1 S. aureus 188 (M r Q r ) 20 20 10 10 10 20 10 10 5 10 128 ≤1 S. aureus 244 (M r ) 20 10 10 10 10 10 10 10 5 10 8 ≤1 S. epidermidis CNS25 20 20 10 10 10 10 10 10 5 10 8 2 S. epidermidis CNS112 (M r Q r ) 20 10 10 10 10 10 10 10 5 10 32 4 S. haemolyticus CNS66 (M r Q r ) 40 20 10 10 20 20 10 20 5 20 64 2 Streptococcus pneumoniae ATCC 49619 20 20 10 10 20 20 20 20 10 20 2 ≤1 Streptococcus pneumoniae BT2 (P r ) 40 20 10 10 20 20 20 20 10 20 8 ≤1 Enterococcus faecalis ATCC 29212 40 20 10 10 20 20 10 20 5 20 32 2 Enterococcus faecalis 141 (VanB Q r ) >40 20 10 5 20 20 10 20 5 20 >128 128 Enterococcus faecium ATCC 35667 >40 20 10 5 10 20 10 20 5 20 4 ≤1 Enterococcus faecium 129 (VanA) 40 20 5 20 10 20 10 10 5 20 8 >128 E. coli ATCC 25922 >40 >40 20 10 40 40 >40 >40 10 40 ≤1 >128 E. coli Misc 239 (TEM-10) >40 >40 20 20 20 20 >40 >40 10 20 ≤1 >128 Klebsiella pneumoniae ThaiK21 (SHV-5 Q r ) >40 >40 20 40 40 40 >40 >40 20 40 16 >128 Enterobacter cloacae 122 (Q r ) >40 >40 20 >40 20 40 >40 >40 10 40 ≤1 >128 Serratia marcescens 69 >40 >40 40 20 40 40 >40 >40 20 40 32 >128 Pseudomonas aeruginosa ATCC 27853 >40 >40 20 20 40 40 >40 40 20 40 2 >128 Pseudomonas aeruginosa 197 (Q r ) >40 >40 40 20 40 40 >40 >40 20 >40 >128 >128 Open in a separate window a MICs are listed as micromolar values for DHAA and peptoid compounds to allow comparison of the same number of molecules per assay.
Techniques: